Clinical Reference · Blood Purification Modalities
Plasma-Based
Therapies
A comprehensive reference for apheresis, filtration, and plasma signaling technologies used in advanced longevity and clinical protocols.
9
Modalities
4
Categories
RX
Supervised Only
Medical Supervision Required
This technical reference is for educational purposes only. All extracorporeal and apheresis-based therapies carry inherent risks and must be conducted exclusively in a certified clinical environment under direct physician oversight. Content does not constitute medical advice or treatment guidance.
Clinical Stratification
Comparative Therapeutic Matrix
| Therapy | Category | Intensity | Primary Mechanism | Evidence | Risk |
|---|---|---|---|---|---|
| DFPP | Filtration | Double filtration; size-selective removal of pathogenic macromolecules (fibrinogen, IgG, LDL). | Clinical | Moderate | |
| Plasma Ozonation | Signaling | Hormetic oxidative stimulus; acute NRF2 pathway activation and antioxidant enzyme upregulation. | Emerging | Low–Mod | |
| TPE / PEX | Exchange | Total plasma volume exchange; broad removal of cytokines, autoantibodies, and pro-inflammatory proteins. | Clinical | Mod–High | |
| INUSpheresis® | Adsorption | Precision elution of environmental toxins, lipopolysaccharides, and heavy metal conjugates. | Emerging | Moderate | |
| Young Plasma Infusion | Experimental | Hypothesized GDF11, TIMP2 signaling and systemic youth-factor enrichment via heterochronic exchange. | Pre-Clinical | Unknown | |
| LDL Apheresis | Filtration | Precision removal of atherogenic lipoproteins (ApoB, Lp(a), LDL-C) via affinity columns. | Established | Moderate | |
| EBO2 / EBOO | Signaling | Extracorporeal blood ozonation and oxygenation combined with micro-filtration of lipids and proteins. | Emerging | Low–Mod | |
| Immunoadsorption | Adsorption | Highly targeted elution of pathological antibodies (anti-dsDNA, AChR-Ab) using protein A or antigen-specific columns. | Clinical | Moderate | |
| Cryofiltration | Filtration | Temperature-dependent precipitation and removal of cryoglobulins and immune complexes. | Clinical | Mod–High |
Apheresis Process
Extracorporeal Circuit — How It Works
STEP 01
Venous Access
Large-bore IV or central catheter placed for continuous blood draw.
STEP 02
Anticoagulation
Heparin or citrate infused to prevent circuit clotting.
STEP 03
Separation
Centrifuge or membrane separator isolates plasma from blood cells.
STEP 04
Filtration / Tx
Target molecules removed or modified per modality (adsorption, ozonation, exchange).
STEP 05
Reinfusion
Treated plasma recombined with cells and returned intravenously.
STEP 06
Monitoring
Vitals, pressure, and electrolytes tracked throughout session.
Modality Classification
Apheresis & Filtration Taxonomy
Signaling & Modulation
01
Plasma Ozonation
Delivers a controlled oxidative dose ex vivo; activates NRF2-mediated antioxidant gene expression and modulates inflammatory cytokine release upon reinfusion.
02
EBO2 / EBOO
Combines ozonation with high-flow oxygenation and integrated microfiltration — removes lipid deposits, oxidised proteins, and microplastics simultaneously.
Selective Precision Removal
03
DFPP (Double Filtration)
Utilizes two distinct filters to selectively clear large molecular weight pathogens while preserving vital smaller proteins.